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Oral Medication: Glycopyrrolate
3 Month Supply for
$50/mo
$40/mo
Powerful prescription-strength oral medication to combat excessive sweating at the source and maintain full-body dryness.
Made with FDA-approved ingredients
Dermatologist prescribed & shipped to you
See results in 4 to 6 weeks
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- Active Ingredients: Glycopyrrolate 1 mg
Glycopyrrolate
Glycopyrrolate is an anticholinergic medication that helps reduce excessive sweating at the source by blocking nerve signals (acetylcholine) that activate your sweat glands. It works systemically to regulate sweating throughout the body.
Up to 85% of people saw a significant reduction in sweating within 4-8 weeks.¹
¹Based on clinical studies of oral glycopyrrolate for primary hyperhidrosis
(Lee et al., JAAD 2012; J Dermatol 2013; Dermatol Ther 2015).
Dermatologist
Consultation
Clinically Backed
Solutions
Once-Daily
Treatment
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Take your medication daily, exactly as prescribed by your healthcare provider. Many people start with 1 mg once daily, then gradually increase to 2-4 mg per day as their body adjusts.
Helpful tip: This medication is often best taken on an empty stomach, about 2 hours before eating.
The Twofold Promise
At Twofold, we believe that everyone deserves to feel comfortable in their own skin — literally. Every Twofold treatment is formulated with clinical precision, prescribed by board-certified dermatologists, and compounded in FDA-registered partner pharmacies. Because when it comes to sweat, you deserve care that’s science-driven, human-centered, and actually works.
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Check out our FAQs or email us at hello@itstwofold.com
We aim to get back to you within 24 hours!
Twofold is a virtual sweat clinic dedicated to helping people manage their hyperhidrosis, or excessive sweating. We provide treatment plans designed by licensed providers to address excessive sweating.
Twofold is all about making expert sweat care simple, effective, and accessible—delivered straight to your door without the need for in-person visits.
Getting personalized sweat care with SweatRx is simple and convenient:
- Complete a quick online consultation to share your symptoms and health history.
- A licensed healthcare provider will review your information and create a customized treatment plan tailored to your needs.
- Receive your prescription treatments delivered right to your door, with ongoing support to ensure your plan is working. We'll check in regularly to answer questions and adjust your treatment as needed.
With your personalized treatment plan in place, you're well on your way to effectively managing your sweating and gaining more control over your daily life.
It usually takes about 4 weeks of daily use to see full, consistent results — so don’t worry if it feels slow a first. Many people will notice changes within their first 1–2 weeks, and it should keep improving from there. Consistent use of your prescribed medication is key to achieving and maintaining the best results. Individual response times can vary based on the severity of your hyperhidrosis and the area being treated.
Oxybutynin, the primary ingredient in our treatment, is FDA-approved for several medical uses, but its use for treating hyperhidrosis is considered "off-label" in the U.S. Off-label prescriptions are a common and legal practice used when providers determine that a treatment is medically appropriate based on a patient's needs.
While oxybutynin's use in hyperhidrosis is off-label, it's widely prescribed by dermatologists due to its proven efficacy in reducing excessive sweating. Many studies have demonstrated the safety and efficacy of oxybutynin, and it has become a well-established treatment among specialists in the field. Our treatment plans are informed by existing research and customized by licensed providers to ensure you receive the best possible care.
Twofold offers quarterly subscription-based treatment plans, at $150 for 3 months of treatment.
Shipping is always free, and there are no hidden fees.
Currently, Twofold does not accept insurance. This allows us to provide greater transparency without surprise costs, copays, or hidden fees.