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Oxybutynin Rx Gel
3 Month Supply for
$50/mo
$40/mo
The oxybutynin gel is a prescription-grade treatment developed with expert dermatologists to deliver targeted, full-body sweat control. Fast-absorbing, invisible on skin, aluminum-free, and crafted for the way you actually live.
Once-nightly application for all-day dryness
Aluminum-free formula
Topical, targeted sweat relief — no needles, no pills
24/7 access to dermatologists specialized in treating hyperhidrosis
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- Active Ingredients: Oxybutynin 8% (Topical Gel)
Oxybutynin
Oxybutynin is a prescription anticholinergic that helps reduce excessive sweating by blocking overactive nerve signals (acetylcholine) that activate sweat glands. Applied topically, it targets sweating right where it happens - while potentially minimizing the systemic side effects of oral medications.
Studies have shown topical oxybutynin can reduce sweating by over 70% with consistent use, significantly improving quality of life.¹
Twofold Gel Base
A proprietary transdermal delivery system engineered to enhance skin absorption and ensure even, consistent distribution. Designed for quick-drying comfort and optimized penetration, it helps the active ingredient reach the sweat glands more effectively - all while leaving skin smooth and residue-free.
¹Topical oxybutynin for hyperhidrosis: A systematic review Wallace,
Carly E. et al. JAAD Reviews, Volume 2, 145 - 148
Dermatologist
Consultation
Clinically Backed
Solutions
Once-Daily
Treatment
30-Day Guarantee
We know you’ve probably tried more than a few treatments-and might be skeptical about trying something new. To make it easier, we offer a 30-day satisfaction guarantee.
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Apply your medication daily, exactly as prescribed by your healthcare provider. This product may be used once daily at night, just before bed. Apply an even layer, and gently rub it in until fully absorbed (2-3 minutes).
For best results, apply to clean, dry skin and allow the gel to fully dry before dressing or lying down. Most people begin noticing results within 2-4 weeks of consistent use.
Helpful tip: Apply only to the areas you want to treat (underarms, hands, feet, or face). Avoid applying immediately after shaving or to irritated skin.
The Twofold Promise
At Twofold, we believe that everyone deserves to feel comfortable in their own skin — literally. Every Twofold treatment is formulated with clinical precision, prescribed by board-certified dermatologists, and compounded in FDA-registered partner pharmacies. Because when it comes to sweat, you deserve care that’s science-driven, human-centered, and actually works.
Still have questions?
Check out our FAQs or email us at hello@itstwofold.com
We aim to get back to you within 24 hours!
Twofold is a virtual sweat clinic dedicated to helping people manage their hyperhidrosis, or excessive sweating. We provide treatment plans designed by licensed providers to address excessive sweating.
Twofold is all about making expert sweat care simple, effective, and accessible—delivered straight to your door without the need for in-person visits.
Getting personalized sweat care with SweatRx is simple and convenient:
- Complete a quick online consultation to share your symptoms and health history.
- A licensed healthcare provider will review your information and create a customized treatment plan tailored to your needs.
- Receive your prescription treatments delivered right to your door, with ongoing support to ensure your plan is working. We'll check in regularly to answer questions and adjust your treatment as needed.
With your personalized treatment plan in place, you're well on your way to effectively managing your sweating and gaining more control over your daily life.
It usually takes about 4 weeks of daily use to see full, consistent results — so don’t worry if it feels slow a first. Many people will notice changes within their first 1–2 weeks, and it should keep improving from there. Consistent use of your prescribed medication is key to achieving and maintaining the best results. Individual response times can vary based on the severity of your hyperhidrosis and the area being treated.
Oxybutynin, the primary ingredient in our treatment, is FDA-approved for several medical uses, but its use for treating hyperhidrosis is considered "off-label" in the U.S. Off-label prescriptions are a common and legal practice used when providers determine that a treatment is medically appropriate based on a patient's needs.
While oxybutynin's use in hyperhidrosis is off-label, it's widely prescribed by dermatologists due to its proven efficacy in reducing excessive sweating. Many studies have demonstrated the safety and efficacy of oxybutynin, and it has become a well-established treatment among specialists in the field. Our treatment plans are informed by existing research and customized by licensed providers to ensure you receive the best possible care.
Twofold offers quarterly subscription-based treatment plans, at $150 for 3 months of treatment.
Shipping is always free, and there are no hidden fees.
Currently, Twofold does not accept insurance. This allows us to provide greater transparency without surprise costs, copays, or hidden fees.